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1.
Rev. peru. med. integr ; 4(1): 15-21, 2019. tab, graf
Article in Spanish | MTYCI, LILACS | ID: biblio-1145754

ABSTRACT

Objetivo: Determinar el efecto del extracto etanólico de Chuquiraga spinosa (huamanpinta) sobre el síndrome metabólico (SM) e hipercolesterolemia inducidas en ratas con fructosa y colesterol. Materiales y Métodos: Se indujo el SM con la administración vía oral de fructosa al 60% P/V durante 90 días y la inducción de hipercolesterolemia fue mediante la administración oral de solución de colesterol a una dosis diaria de 120 mg/kg suspendida en goma de tragacanto al 2%. Se formaron 06 grupos de 15 animales cada grupo, dividido en grupo blanco negativo (solución salina fisiológica) y positivo (fructosa más colesterol), extracto etanólico a dosis de 50, 250 y 500 mg/kg y un grupo atorvastatina más enalapril a 20 mg/kg (se administró fructosa más colesterol a todos los grupos). Los tratamientos respectivos se iniciaron en el día 31 posinducción y se continuó con la inducción coadministrando los tratamientos hasta los 90 días. Se determinó el perfil lipídico, glicemia y niveles de presión arterial. En la determinación de la toxicidad crónica se realizó la evaluación a nivel hematológico y bioquímico de todos los grupos que fueron inducidos y recibieron tratamiento. Resultados: Se obtuvo una disminución de los niveles de colesterol total, triglicéridos, glucosa, presión arterial y del peso corporal, así como una elevación de los niveles de HDL-colesterol, que fueron estadísticamente significativos (p<0,05). En la determinación de la toxicidad crónica se observo que no hubo toxicidad y no se evidenció alteraciones anatomopatológicas. Conclusiones: El extracto etanólico de Chuquiraga spinosa presenta efecto positivo sobre los niveles de perfil lipídico, glucosa y presión arterial inducido en ratas, sin efectos tóxicos.


Objective: To determine the effect of ethanolic extract of Chuquiraga spinosa (huamanpinta) on the metabolic syndrome and hypercholesterolemia in rats induced with fructose and cholesterol. Material and methods: SM was induced in rats with oral administration of 60% fructose for 90 days and the induction of hypercholesterolemia was by oral administration of cholesterol solution at a daily dose of 120 mg/kg suspended in gum tragacanth 2 %. Six groups of 15 animals were formed in each group, divided into negative white group (physiological saline solution) and positive (fructose plus cholesterol), ethanolic extract at doses of 50, 250 and 500 mg/kg and one atorvastatin plus enalapril group at 20 mg/Kg. The respective treatments were initiated on day 31 postinduction and continued induction along with treatments up to 90 days. The lipid profile, glycemia and blood pressure levels were determined. In the determination of chronic toxicity, hematological and biochemical evaluation of all the groups that were induced and treated were performed. Results: There was a decrease in total cholesterol, triglycerides, glucose, blood pressure and body weight, as well as a rise in HDL-cholesterol levels, which were statistically significant (p <0.05). In the determination of chronic toxicity, it was observed that there was no toxicity and no anatomopathological alterations were evidenced. Conclusions: The ethanolic extract of Chuquiraga spinosa has a positive effect on the metabolic syndrome and induced hypercholesterolemia in rats, without toxic effects.


Subject(s)
Animals , Rats , Asteraceae , Metabolic Syndrome , Hypercholesterolemia , Plants, Medicinal , Plant Extracts , Medicine, Traditional
2.
Article | IMSEAR | ID: sea-187788

ABSTRACT

Aims: Oils with high levels of omega-3 are being commercialized as the natural supplement to avoid serious consequences related to metabolic syndrome. Sacha inchi (Plukenetia volubilis) oil is a natural product used as a nutraceutical in Peru. Otherwise, genotoxicity is the main test for assessing the toxicity of drugs, food and other substances. Sacha inchi is known as an oil with high content of omega-3 and others polyunsaturated fatty acids. The objective of this study was to determine the antimutagenic effect of Plukenetia volubilis (Sacha inchi) oil in BALB/c mice. Study Design: Sacha inchi oil was obtained using standardized methods in order to determine its antimutagenic effect in BALB/c mice by using micronucleus test, according to the Organization of Economic Co-operation and Development (OECD) guidelines. Place and Duration of Study: Laboratory of Experimental Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru, from January to February 2017. Methodology: A total of 100 Balb/C albino mice (20 - 30 g) of male sex were randomly divided into five groups (n = 20). The groups were normal saline group (NS), cyclophosphamide group (CP; 40 mg/kg i.p.) and the three other groups received cyclophosphamide and Sacha inchi oil of concentrations 10, 100 and 1000 mg/kg respectively. The substances were administered three times during 24 hours. The genotoxicity in mice was evaluated determining micronucleus levels in blood and bone marrow. Results: CP group showed higher micronucleus levels in blood and bone marrow compared with Sacha inchi oil 10, 100 and 1000 mg/kg groups (ANOVA Test P < 0.001 Scheffe’s Post Hoc P < 0.001). Conclusion: In our findings, Sacha inchi oil was not mutagenic under experimental conditions.

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